Tuberculostatic Derivatives of p-Aminobenzoic Acid. III. Heterocyclic Derivatives of 4-Aminosalicylic Acid.
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منابع مشابه
Separation of p-Aminobenzoic Acid Derivatives
According to the literature, p-aminobenzoic acid (PAB) is excreted in the urine mostly as the free acid and its N-acetyl derivative; the remaining part is eliminated conjugated with glucuronic acid and as p-aminohippuric acid (PAH) (Ellinger & Hensel, 1914'; Hensel, 1914; Cohen & McGilvery, 1946; Salassa, Bollman & Dry, 1948). There is no agreement concerning the formation of PAH. Thus, Beyer, ...
متن کاملMechanism of competitive inhibition of p-aminobenzoic acid oxidation by p-aminosalicylic acid.
The proposed mechanism(s) associated with the inhibition of essential metabolic reactions by various compounds has received a great deal of attention in recent years, since antimetabolites have proved useful in several chemotherapeutic areas and in studying various metabolic reactions. The significance of p-aminobenzoic acid in microbial nutrition was first emphasized when Woods (1940) and Wood...
متن کاملSynthesis, characterization, and tuberculostatic activity of novel 2-(4-nitrobenzoyl)hydrazinecarbodithioic acid derivatives
ABSTRACT A series of novel S-esters of 2-(4-nitrobenzoyl)hydrazinecarbodithioic acid and S,S'-diesters of (4-nitrobenzoyl)carbonohydrazonodithioic acid were synthesized by reaction of 4-nitrobenzohydrazide and N-methyl-4-nitrobenzohydrazide with carbon disulfide and alkyl halides in the presence of triethylamine. Novel 5-(4-nitrophenyl)-1,3,4-oxadiazoles were also obtained. The structures were ...
متن کاملTHE ANTIBACTERIAL ACTION OF DERIVATIVES AND ANALOGUES OF p-AMINOBENZOIC ACID
The bacteriostasis induced by the sulfonamide drugs is reversed by p-aminobenxoic acid (PAB) in appropriate concentrations (1). It is now well established that PAB is a normal constituent of cells (2) and that the bacteriostatic effects of the sulfonamides are explicable in terms of their structural similarity to PAB (3). The precise rble of PAB in cellular metabolism has yet to be clarified bu...
متن کاملThe In Vitro Effects of N-Substituted p-Aminobenzoic Acid Derivatives upon Sulfonamides.
The discovery by Woods (1940) that small amounts of p-aminobenzoic acid could block the antibacterial effects of the sulfonamides served to stimulate a number of investigations on sulfonamide p-aminobenzoic acid relationships. Woods's initial finding soon led to the observations that many derivatives of p-aminobenzoic acid also exhibited antisulfonamide activity. Keltch et al. (1941) demonstrat...
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ژورنال
عنوان ژورنال: Acta Chemica Scandinavica
سال: 1952
ISSN: 0904-213X
DOI: 10.3891/acta.chem.scand.06-0161